4.6 Review

Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy

期刊

CANCERS
卷 13, 期 13, 页码 -

出版社

MDPI
DOI: 10.3390/cancers13133276

关键词

breast cancer metastasis; genomic analysis; diagnosis; prognosis; therapy

类别

资金

  1. National Cancer Institute [1R03CA230573]
  2. Department of Defense [W81XWH-21-1-0261]
  3. Emerson Collective Cancer Research Fund [ECCRF191684]
  4. Qatar National Research Fund [NPRP12S-0317-190379]

向作者/读者索取更多资源

Metastasis remains the leading cause of death in breast cancer patients worldwide, with genomic profiling methods revolutionizing our understanding of this complex process. There is a lack of accurate prognostic indicators and effective treatments for metastasis, highlighting the importance of recent advancements in functional genomic analysis for potential prognostic and therapeutic implications.
Simple Summary Metastasis remains the greatest cause of fatalities in breast cancer patients world-wide. The process of metastases is highly complex, and the current research efforts in this area are still rather fragmented. The revolution of genomic profiling methods to analyze samples from human and animal models dramatically improved our understanding of breast cancer metastasis. This article summarizes the recent breakthroughs in genomic analyses of breast cancer metastasis and discusses their implications for prognostic and therapeutic applications. Breast cancer (BC) is one of the most diagnosed cancers worldwide and is the second cause of cancer related death in women. The most frequent cause of BC-related deaths, like many cancers, is metastasis. However, metastasis is a complicated and poorly understood process for which there is a shortage of accurate prognostic indicators and effective treatments. With the rapid and ever-evolving development and application of genomic sequencing technologies, many novel molecules were identified that play previously unappreciated and important roles in the various stages of metastasis. In this review, we summarize current advancements in the functional genomic analysis of BC metastasis and discuss about the potential prognostic and therapeutic implications from the recent genomic findings.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据