4.6 Review

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

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Summary: Photodynamic Therapy (PDT) is a cancer treatment that utilizes a photosensitizer to activate reactive oxygen species, killing tumor cells and stimulating the host immune system. Factors such as the structure of the photosensitizer, drug-light interval, rate of light delivery, and combination with adjuvants can affect the efficiency of the immune response. The success of checkpoint inhibitors in tumor immunotherapy opens up the possibility for investigating PDT in combination with other approaches in clinical scenarios.

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Summary: PDT is a therapy based on specific light sources, photosensitizers, and oxygen. LED light sources have shown promising results in PDT applications, particularly in the treatment of breast cancer cells with 5-ALA PDT. The study demonstrated decreased cell viability and increased apoptosis in breast cancer cells after LED irradiation.

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Summary: Cancer is a major global health issue and photodynamic therapy using photosensitizers is an approved therapeutic option. The success of this therapy depends on the quality and improvement of photosensitizer drugs, with bioconjugation and encapsulation with targeting moieties playing a key role in developing more efficient photosensitizers for cancer treatment. Despite significant advances, the development of next-generation photosensitizers is still mainly in the developmental stage.

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