New Indications for Liver Transplantation

Liver transplantation (LT) is an important therapeutic option for the treatment of several liver diseases. Modern LT is characterized by remarkable improvements in post-transplant patient survival, graft survival, and quality of life. Thanks to these great improvements, indications for LT are expanding. Nowadays, clinical conditions historically considered exclusion criteria for LT, have been considered new indications for LT, showing survival advantages for patients. In this review, we provide an updated overview of the principal newer indications for LT, with particular attention to alcoholic hepatitis, acute-on-chronic liver failure (ACLF), cholangiocarcinoma and colorectal cancer metastases.

Automated summary

Liver transplantation has seen remarkable improvements in post-transplant patient survival, graft survival, and quality of life in recent years. Due to these advancements, indications for liver transplantation are expanding to include clinical conditions historically considered exclusion criteria, showing survival advantages for patients. In this review, newer indications for liver transplantation such as alcoholic hepatitis, acute-on-chronic liver failure (ACLF), cholangiocarcinoma, and colorectal cancer metastases are discussed.