4.7 Article

Ocular Comorbidities in Rosacea: A Case-Control Study Based on Seven Institutions

期刊

JOURNAL OF CLINICAL MEDICINE
卷 10, 期 13, 页码 -

出版社

MDPI
DOI: 10.3390/jcm10132897

关键词

ocular comorbidities; rosacea; multi-institutional case-control study

资金

  1. Catholic University of Korea
  2. Dermatology Alumni Fund of the Catholic University of Korea
  3. Institute of Bio-Medical convergence
  4. Incheon St. Mary's Hospital
  5. National Research Foundation of Korea (NRF) - South Korean Government [2020R1F1A1048238]
  6. National Research Foundation of Korea [2020R1F1A1048238] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This study found that ocular comorbidities such as blepharitis, conjunctivitis, glaucoma, dry eye syndrome, and chalazion are more prevalent among Koreans with rosacea. Female subjects and individuals younger than 50 exclusively showed higher odds for chalazion. Clinicians should proactively check ocular symptoms in rosacea and consider joint care with an ophthalmologist when needed.
Rosacea is a facial inflammatory dermatosis that is linked with various systemic illnesses. With regards to the eye, rosacea patients have been described to manifest ocular surface changes, such as blepharitis and conjunctivitis. However, studies that examine the association of rosacea with a wider array of ocular diseases are limited. Thus, our aim was to identify the range of ocular comorbidities in the Korean patient population and create a reference data set. A multi-institutional, case-control study was conducted, where 12,936 rosacea patients and an equal number of sex- and age-matched control subjects were extracted over a 12-year period. We were able to discover a notable association between rosacea and blepharitis (adjusted odds ratio (aOR) 3.44; 95% confidence interval, 2.71-4.36, p < 0.001), conjunctivitis (aOR 1.65; 95% CI, 1.50-1.82, p < 0.001), glaucoma (aOR 1.93; 95% CI, 1.70-2.20, p < 0.001), dry eye syndrome (aOR 1.89; 95% CI, 1.70-2.09, p < 0.001), and chalazion (aOR 3.26; 95% CI, 1.41-7.57, p = 0.006) from logistic regression analysis. Female subjects and individuals younger than 50 exclusively showed higher odds for chalazion. Our study suggests that ocular comorbidities (i.e., glaucoma, dry eye syndrome, and chalazion as well as blepharitis and conjunctivitis) are more prevalent among Koreans with rosacea. Clinicians should proactively check ocular symptoms in rosacea and employ joint care with an ophthalmologist in cases of need.

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