Nocturnal Oxygen Saturation Parameters as Independent Risk Factors for Type 2 Diabetes Mellitus among Obstructive Sleep Apnea Patients

Obstructive sleep apnea (OSA) is a recognized independent risk factor for metabolic disorders, type 2 diabetes mellites (DM2) in particular. Therefore, the study aimed to assess the influence of nocturnal oxygen saturation parameters on the onset of DM2 among OSA patients. The study consisted of 549 participants, who underwent polysomnography examination. Based on apnea hypopnea index (AHI), 465 patients were diagnosed with OSA. One hundred and seven individuals had comorbid DM2. Cox regression models were used to assess the effect of oxygen saturation parameters on the onset of DM2. Classification and regression trees (CART) analysis was used to assess the onset of the DM2 in the study group in context of oxygen saturation variables. One-way Cox regression showed higher risk of earlier DM2 for increased values of BMI, AHI, decreased basal O-2 and O-2 nadir value, while lowered mean O-2 desaturation has not shown statistical significance. In the CART analysis, the following cut-off points 92.2%, 81.7%, 87.1% were determined for basal O-2, O-2 nadir and mean O-2 desaturation, respectively, with the first two parameters being statistically significant. Therefore, basal O-2 is independent from AHI, BMI and age is a risk factor of DM2 among OSA patients.

Automated summary

The study found that in OSA patients, basal O2 saturation is independent of AHI, BMI, and age, and is a risk factor for type 2 diabetes. One-way Cox regression analysis showed a higher risk of earlier type 2 diabetes for increased BMI, AHI, decreased basal O2, and O2 nadir values, while lowered mean O2 desaturation did not show statistical significance. In CART analysis, cut-off points of 92.2%, 81.7%, and 87.1% were determined for basal O2, O2 nadir, and mean O2 desaturation, with the first two parameters being statistically significant.