期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/jcm10194326
关键词
myocardial infarction; coronary artery disease; SYNTAX score; osteoprotegerin; vascular calcification
资金
- University Hospital of Dijon
- Association de Cardiologie de Bourgogne
- Federation Francaise de Cardiologie
- Agence Regionale de Sante de Bourgogne Franche-Comte
- Conseil Regional de Bourgogne Franche-Comte
The study found an association between serum OPG levels and coronary lesion complexity in patients with acute myocardial infarction, which was not influenced by factors such as hypercholesterolemia, cardiovascular history, and reduced glomerular filtration rate.
Background. Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. Aim. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Methods. Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3-6)), medium (11 (9-13)) and high (20 (18-23)) tertiles of SYNTAX score. Results. Among the 378 patients included, there was a gradual increase in age, rate of diabetes, anterior wall location, and a reduction in left ventricular ejection fraction across the SYNTAX tertiles. OPG levels significantly increased across the tertiles (962 (782-1497), 1240 (870-1707), and 1464 (1011-2129) pg/mL, respectively (p < 0.001)). In multivariate analysis, OPG [OR(CI95%): 2.10 (1.29-3.49) 0.003], were associated with the high SYNTAX group, beyond hypercholesterolemia, CV history and reduced glomerular filtration rate. Conclusion. We found an association between OPG levels and coronary lesions complexity patients with acute MI.
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