期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/jcm10122578
关键词
OX40L; OX40; atopic dermatitis; Th1 cell; Th2 cell; Th17 cell; dendritic cell
The OX40L-OX40 axis plays a crucial role in the sustained activation and expansion of effector T cells, and has shown therapeutic potential in diseases like atopic dermatitis.
OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L-OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naive and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L-OX40 axis as a promising target for the treatment of atopic dermatitis.
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