4.7 Article

Colorectal Cancer Risk in Women with Gynecologic Cancers-A Population Retrospective Cohort Study

期刊

JOURNAL OF CLINICAL MEDICINE
卷 10, 期 14, 页码 -

出版社

MDPI
DOI: 10.3390/jcm10143127

关键词

colorectal cancer; gynecologic cancer; retrospective cohort study; colonoscopy screening

资金

  1. Ministry of Health and Welfare, Taiwan [MOHW109-TDU-B-212-114004]
  2. MOST Clinical Trial Consortium for Stroke [MOST 109-2321-B-039-002]
  3. Ministry of Science and Technology, Taiwan [MOST108-2410-H-039-001, MOST109-2410-H-039-001]
  4. ChinaMedical University, Taiwan [CMU109-MF-119]
  5. Tseng-Lien Lin Foundation, Taichung, Taiwan

向作者/读者索取更多资源

Women with gynecologic malignancy, especially endometrial and ovarian cancer, are at a higher risk of developing colorectal cancer. The incidence of CRC increases with age, and early cancer treatments may help reduce the risk.
We conducted a retrospective cohort study to evaluate the subsequent colorectal cancer (CRC) risk for women with gynecologic malignancy using insurance claims data of Taiwan. We identified patients who survived cervical cancer (N = 25,370), endometrial cancer (N = 8149) and ovarian cancer (N = 7933) newly diagnosed from 1998 to 2010, and randomly selected comparisons (N = 165,808) without cancer, matched by age and diagnosis date. By the end of 2011, the incidence and hazard ratio (HR) of CRC were estimated. We found that CRC incidence rates were 1.26-, 2.20-, and 1.61-fold higher in women with cervical, endometrial and ovarian cancers, respectively, than in comparisons (1.09/1000 person-years). The CRC incidence increased with age. Higher adjusted HRs of CRC appeared within 3 years for women with endometrial and ovarian cancers, but not until the 4th to 7th years of follow up for cervical cancer survivals. Cancer treatments could reduce CRC risks, but not significantly. However, ovarian cancer patients receiving surgery alone had an incidence of 3.33/1000 person-years for CRC with an adjusted HR of 3.79 (95% CI 1.11-12.9) compared to patients without any treatment. In conclusion, gynecologic cancer patients are at an increased risk of developing CRC, sooner for those with endometrial or ovarian cancer than those with cervical cancer.

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