Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics Approaches

Current epidemics, such as AIDS or flu, and the emergence of new threatening pathogens, such as the one causing the current coronavirus disease 2019 (COVID-19) pandemic, represent major global health challenges. While vaccination is an important part of the arsenal to counter the spread of viral diseases, it presents limitations and needs to be complemented by efficient therapeutic solutions. Intricate knowledge of host-pathogen interactions is a powerful tool to identify host-dependent vulnerabilities that can be exploited to dampen viral replication. Such host-directed antiviral therapies are promising and are less prone to the development of drug-resistant viral strains. Here, we first describe proteomics-based strategies that allow the rapid characterization of host-pathogen interactions. We then discuss how such data can be exploited to help prioritize compounds with potential host-directed antiviral activity that can be tested in preclinical models.

Automated summary

The current global health challenges posed by diseases like AIDS, flu, and the COVID-19 pandemic highlight the importance of not only vaccination but also the development of efficient therapeutic solutions. Understanding host-pathogen interactions can help identify vulnerabilities in the host that can be targeted to reduce viral replication. Utilizing proteomics-based strategies can aid in identifying potential compounds with host-directed antiviral activity for testing in preclinical models.