期刊
MSYSTEMS
卷 6, 期 4, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/mSystems.00675-21
关键词
gut biogeography; microbiota; physical perturbations
类别
资金
- NSERC
- CIHR
- CIFAR
- Michael Smith Foundation for Health Research Scholar Award
- Paul Allen Distinguished Investigator Award
- Canada Foundation for Innovation
- Canadian Microbiome Initiative 2
- Crohn's and Colitis Canada
- Weston Foundation: Weston Family Microbiome Initiative
- Scialog
- Research Corporation for Science Advancement
- Frederick Gardner Cottrell Foundation
- Paul G. Allen Frontiers Group [27872]
- Johnson & JohnsonWomen in STEM2D Award
Living systems are strongly impacted by physical factors, and small changes in parameters can have profound effects. In competitive environments, physical perturbations can lead to long-term consequences for microbial communities.
Living systems, from micro-to macro-scales, are strongly impacted by physical factors such as temperature, pH, and the concentration of compounds in their surrounding environment. In the macro-world, it is obvious that small changes in these parameters can have profound, and even devastating, impacts on an ecosystem. For example, in the case of global warming, a change in climate, and specifically a few degrees in temperature, has taken one million species of animals to the brink of extinc-tion. Scale things down 6 orders of magnitude, our gut microbiota also experiences similar changes in temperature due to disease. In this highly competitive environment, physical perturbations inflict long-term consequences on the microbiota ecosystem and, in turn, on the host organism. My laboratory is exploring the feedback between the gut's physical environment, the microbiota, and disease. Our research highlights the importance of measuring physical parameters for the prediction of microbial dynamics and microbiota therapies.
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