期刊
ACTA PHARMACEUTICA SINICA B
卷 12, 期 2, 页码 581-599出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2021.08.027
关键词
SARS-CoV-2; COVID-19; Antiviral drugs; Drug design; Medicinal chemistry strategies
资金
- Shandong Provincial Key Research and Development Project (China) [2019JZZY021011]
- Foreign Cultural and Educational Ex-perts Project (China) [GXL20200015001]
- Outstanding Youth Fund of Shandong Province (China) [ZR2020JQ31]
- Qilu Young Scholars Program of Shandong University
- Taishan Scholar Program at Shandong Province
This article provides a brief overview of medicinal chemistry strategies for the development of effective SARS-CoV-2 inhibitors, highlighting representative examples.
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. (c) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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