期刊
ACTA PHARMACEUTICA SINICA B
卷 12, 期 1, 页码 107-134出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2021.05.031
关键词
Cancer immunotherapy; Nanomaterials; Cancer-immunity cycle; Drug delivery; ICD inducers; Immunomodulators; Photothermal therapy; Photodynamic therapy; Radio sensitizer
资金
- National Natural Science Foundation of China [22007106, 31800842, 31922042, 81771966]
- Technology & Innovation Commission of Shenzhen Municipality, China [JCYJ20180507181654186, JCYJ20170818162637217]
- Fundamental Research Funds for the Central Universities [2020-RC320-002, 2019PT320028]
- China Postdoctoral Science Foundation, China [2019TQ0396]
The immune system plays a critical role in cancer initiation and progression. Recent advancements in nanomaterials have expanded their applications in cancer immunotherapies, including drug carriers, inducers of immunogenic cell death, and immunomodulators. Nanomaterials can act as an integrated platform targeting multiple steps of the cancer-immunity cycle simultaneously, enhancing the effectiveness of anticancer immune response.
The immune system is involved in the initiation and progression of cancer. Research on cancer and immunity has contributed to the development of several clinically successful immunotherapies. These immunotherapies often act on a single step of the cancer-immunity cycle. In recent years, the discovery of new nanomaterials has dramatically expanded the functions and potential applications of nanomaterials. In addition to acting as drug-delivery platforms, some nanomaterials can induce the immunogenic cell death (ICD) of cancer cells or regulate the profile and strength of the immune response as immunomodulators. Based on their versatility, nanomaterials may serve as an integrated platform for multiple drugs or therapeutic strategies, simultaneously targeting several steps of the cancer-immunity cycle to enhance the outcome of anticancer immune response. To illustrate the critical roles of nanomaterials in cancer immunotherapies based on cancer-immunity cycle, this review will comprehensively describe the crosstalk between the immune system and cancer, and the current applications of nanomaterials, including drug carriers, ICD inducers, and immunomodulators. Moreover, this review will provide a detailed discussion of the knowledge regarding developing combinational cancer immunotherapies based on the cancer-immunity cycle, hoping to maximize the efficacy of these treatments assisted by nanomaterials. (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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