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Nitazoxanide: A first-in-class broad-spectrum antiviral agent
Jean-Francois Rossignol
ANTIVIRAL RESEARCH (2014)
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
Lisa Oestereich et al.
ANTIVIRAL RESEARCH (2014)
Characterization of IIPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class Ill phosphoinositide 3-kinase
Ruzica Bago et al.
BIOCHEMICAL JOURNAL (2014)
Homoharringtonine and omacetaxine for myeloid hematological malignancies
Shuqing Lu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2014)
X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
Yahira M. Baez-Santos et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study
Ali S. Omrani et al.
LANCET INFECTIOUS DISEASES (2014)
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
William E. Dowdle et al.
NATURE CELL BIOLOGY (2014)
Influence of hydrophobic and electrostatic residues on SARS-coronavirus S2 protein stability: Insights into mechanisms of general viral fusion and inhibitor design
Halil Aydin et al.
PROTEIN SCIENCE (2014)
Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
Vineet D. Menachery et al.
VIRUS RESEARCH (2014)
The Coronavirus Nucleocapsid Is a Multifunctional Protein
Ruth McBride et al.
VIRUSES-BASEL (2014)
Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor
Lu Lu et al.
NATURE COMMUNICATIONS (2014)
The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
Jared M. Lucas et al.
CANCER DISCOVERY (2014)
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
Wilson Wong et al.
ELIFE (2014)
Clemizole Hydrochloride Is a Novel and Potent Inhibitor of Transient Receptor Potential Channel TRPC5
Julia M. Richter et al.
MOLECULAR PHARMACOLOGY (2014)
Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication
Neda Nasheri et al.
CHEMISTRY & BIOLOGY (2013)
Synthesized Peptide Inhibitors of HIV-1 gp41-dependent Membrane Fusion
Yuxian He
CURRENT PHARMACEUTICAL DESIGN (2013)
Systematic review of clofazimine for the treatment of drug-resistant tuberculosis
M. Gopal et al.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE (2013)
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
Lei Wang et al.
NATURE COMMUNICATIONS (2013)
Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase
Adeyemi O. Adedeji et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus
Kylie M. Wagstaff et al.
BIOCHEMICAL JOURNAL (2012)
Development of novel entry inhibitors targeting emerging viruses
Yanchen Zhou et al.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2012)
Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain
Martha Schneider et al.
JOURNAL OF VIROLOGY (2012)
New 3-amidinophenylalanine-derived inhibitors of matriptase
Maya Hammami et al.
MEDCHEMCOMM (2012)
Emodin inhibits current through SARS-associated coronavirus 3a protein
Silvia Schwarz et al.
ANTIVIRAL RESEARCH (2011)
2,6-Bis-arylmethyloxy-5-hydroxychromones with antiviral activity against both hepatitis C virus (HCV) and SARS-associated coronavirus (SCV)
Mi Kyoung Kim et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex
Etienne Decroly et al.
PLOS PATHOGENS (2011)
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model
Benelita Tina Elie et al.
BIOCHIMIE (2010)
Telmisartan: a review of its pharmacodynamic and pharmacokinetic properties
Sylvia Deppe et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)
Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae
Barry R. O'Keefe et al.
JOURNAL OF VIROLOGY (2010)
Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors
I-Jung Liu et al.
ANTIVIRAL RESEARCH (2009)
Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase
Chaewoon Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
High-Throughput Cell-Based Screen for Chemicals That Inhibit Infection by Simian Virus 40 and Human Polyomaviruses
Edward C. Goodwin et al.
JOURNAL OF VIROLOGY (2009)
The pharmacokinetics and interactions of ivermectin in humans - A mini-review
Aranzazu Gonzalez Canga et al.
AAPS JOURNAL (2008)
Molecular dynamic simulations analysis of ritronavir and lopinavir as SARS-CoV 3CLpro inhibitors
Veena Nukoolkarn et al.
JOURNAL OF THEORETICAL BIOLOGY (2008)
Differential role for low pH and cathepsin-mediated cleavage of the viral spike protein during entry of serotype II feline coronaviruses
Andrew D. Regan et al.
VETERINARY MICROBIOLOGY (2008)
SARS coronavirus replicase proteins in pathogenesis
Rachel L. Graham et al.
VIRUS RESEARCH (2008)
Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway
Makoto Ujike et al.
JOURNAL OF VIROLOGY (2008)
The intracellular sites of early replication and budding of SARS-coronavirus
Silke Stertz et al.
VIROLOGY (2007)
Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
Tin-Yun Ho et al.
ANTIVIRAL RESEARCH (2007)
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
Anna C. Rutherford et al.
JOURNAL OF CELL SCIENCE (2006)
Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry
Zhaozhu Qiu et al.
JOURNAL OF VIROLOGY (2006)
Understanding helicases as a means of virus control
D. N. Frick et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Viral and cellular RNA helicases as antiviral targets
AD Kwong et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Keynote review:: Progress in targeting HIV-1 entry
HJP Ryser et al.
DRUG DISCOVERY TODAY (2005)
The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus
JA Tanner et al.
CHEMISTRY & BIOLOGY (2005)
Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors
SW Liu et al.
LANCET (2004)
Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings
CM Chu et al.
THORAX (2004)
Small molecules targeting severe acute respiratory syndrome human coronavirus
CY Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Severe acute respiratory syndrome coroavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides
BJ Bosch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
New developments in anti-HIV chemotherapy
E De Clercq
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)