期刊
ACTA PHARMACEUTICA SINICA B
卷 12, 期 3, 页码 1473-1486出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2021.07.020
关键词
Nanoprobe; 7-Amino actinomycin D; Intermediate filament protein; Tumor image; Antitumor therapy; Integrin avβ 3
资金
- National Natural Science Foundation of China [81603016, 81773624, 81900453]
- Natural Science Foundation of Jiangsu Province [BK20160706, BE2017746]
- National Science and Technology Major Project [2018ZX09301026-005, 2020ZX09201015]
The development of nanomedicine has made significant breakthroughs in cancer treatment, but the biocompatibility and targeted penetration of nanomaterials remain limitations. A bifunctional nanoparticle, synthesized through the self-assembly of intermediate filaments with RGD peptide and encapsulation of 7-AAD molecules, serves as a fluorescent imaging probe for tumor treatment visualization.
The development of nanomedicine has recently achieved several breakthroughs in the field of cancer treatment; however, biocompatibility and targeted penetration of these nanomaterials remain as limitations, which lead to serious side effects and significantly narrow the scope of their application. The self-assembly of intermediate filaments with arginine-glycine-aspartate (RGD) peptide (RGDIFP) was triggered by the hydrophobic cationic molecule 7-amino actinomycin D (7-AAD) to synthesize a bifunctional nanoparticle that could serve as a fluorescent imaging probe to visualize tumor treatment. The designed RGD-IFP peptide possessed the ability to encapsulate 7-AAD molecules through the formation of hydrogen bonds and hydrophobic interactions by a one-step method. This fluorescent nanoprobe with RGD peptide could be targeted for delivery into tumor cells and released in acidic environments such as endosomes/lysosomes, ultimately inducing cytotoxicity by arresting tumor cell cycling with inserted DNA. It is noteworthy that the RGD-IFP/7-AAD nanoprobe tail-vein injection approach demonstrated not only high tumor-targeted imaging potential, but also potent antitumor therapeutic effects in vivo. The proposed strategy may be used in peptide-driven bifunctional nanoparticles for precise im-aging and cancer therapy. @ 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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