期刊
SCIENCE ADVANCES
卷 7, 期 36, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abh0273
关键词
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资金
- Max Planck Society
- European Research Council (ERC) [834531]
This study proposes a personalized approach using patient blood-derivable biomaterials to construct wireless medical micromachines, aiming to alleviate safety risks from biocompatibility issues. The micro-machines demonstrated in this study exhibit multi-responsive and pH-responsive functions for controlled cargo delivery and release applications. The use of proteinaceous fabrics also enables enzymatic degradability, lowering potential risks of long-term toxicity.
While recent wireless micromachines have shown increasing potential for medical use, their potential safety risks concerning biocompatibility need to be mitigated. They are typically constructed from materials that are not intrinsically compatible with physiological environments. Here, we propose a personalized approach by using patient blood-derivable biomaterials as the main construction fabric of wireless medical micromachines to alleviate safety risks from biocompatibility. We demonstrate 3D printed multiresponsive microswimmers and microrollers made from magnetic nanocomposites of blood plasma, serum albumin protein, and platelet lysate. These micro-machines respond to time-variant magnetic fields for torque-driven steerable motion and exhibit multiple cycles of pH-responsive two-way shape memory behavior for controlled cargo delivery and release applications. Their proteinaceous fabrics enable enzymatic degradability with proteinases, thereby lowering risks of long-term toxicity. The personalized micromachine fabrication strategy we conceptualize here can affect various future medical robots and devices made of autologous biomaterials to improve biocompatibility and smart functionality.
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