期刊
SCIENCE ADVANCES
卷 7, 期 25, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abg4693
关键词
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资金
- Deutsche Forschungsgemeinschaft [FOR 2143: GE 1175/2-2, VI 353-1/2, GRK 1589]
- Federal Ministry of Education and Research Germany [01GQ 1403]
- European Research Council [864243]
- European Research Council (ERC) [864243] Funding Source: European Research Council (ERC)
This study reveals that inhibition by fast-spiking interneurons in the rat superficial presubiculum is organized in the form of a dominant super-reciprocal microcircuit motif. The unique connectivity arises from the asymmetric, polarized morphology of fast-spiking interneuron axons, improving head direction tuning of pyramidal cells. The structured inhibition based on asymmetrical axons is proposed as an overarching spatial connectivity principle for tailored computation across brain regions.
In cortical microcircuits, it is generally assumed that fast-spiking parvalbumin interneurons mediate dense and nonselective inhibition. Some reports indicate sparse and structured inhibitory connectivity, but the computational relevance and the underlying spatial organization remain unresolved. In the rat superficial presubiculum, we find that inhibition by fast-spiking interneurons is organized in the form of a dominant super-reciprocal microcircuit motif where multiple pyramidal cells recurrently inhibit each other via a single interneuron. Multineuron recordings and subsequent 3D reconstructions and analysis further show that this nonrandom connectivity arises from an asymmetric, polarized morphology of fast-spiking interneuron axons, which individually cover different directions in the same volume. Network simulations assuming topographically organized input demonstrate that such polarized inhibition can improve head direction tuning of pyramidal cells in comparison to a blanket of inhibition. We propose that structured inhibition based on asymmetrical axons is an overarching spatial connectivity principle for tailored computation across brain regions.
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