4.8 Article

Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness

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SCIENCE ADVANCES
卷 7, 期 24, 页码 -

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abg1512

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资金

  1. Wellcome Trust [200102/Z/15/Z, 094849/Z/10/Z]
  2. NIHR academic clinical lectureship
  3. UCL Welcome PhD Fellowship for Clinicians [102186/B/13/Z]
  4. Medical Research Council-UK [MC_U120097115]
  5. Maudsley Charity [666]
  6. National Institute for Health Research (NIHR) Biomedical Research Centre at South Londonn and Maudsley NHS Foundation Trust and King's College London
  7. MRC [MC_U120097115] Funding Source: UKRI
  8. Wellcome Trust [200102/Z/15/Z] Funding Source: Wellcome Trust

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The study found shared information between dopamine signaling and neural activity, with patterns of striatal dopamine signaling and cortical blood flow containing shared information in healthy volunteers. The results reveal the relevance for understanding diseases where abnormalities of cortical activity and dopamine signaling coexist in neuropsychiatric illnesses.
Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural activity. The nature of this relationship between local dopamine signaling and brain-wide neuronal activity is not clearly defined and has relevance for neuropsychiatric illnesses where abnormalities of cortical activity and dopamine signaling coexist. Using simultaneous PET-MRI in healthy volunteers, we find strong evidence that patterns of striatal dopamine signaling and cortical blood flow (an index of local neural activity) contain shared information. This shared information links amphetamine-induced changes in gradients of striatal dopamine receptor availability to changes in brain-wide blood flow and is informed by spatial patterns of gene expression enriched for genes implicated in schizophrenia, bipolar disorder, and autism spectrum disorder. These results advance our knowledge of the relationship between cortical function and striatal dopamine, with relevance for understanding pathophysiology and treatment of diseases in which simultaneous aberrations of these systems exist.

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