期刊
SCIENCE ADVANCES
卷 7, 期 32, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abj1691
关键词
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资金
- NIH-NIAID [R01 AI127565]
- Iowa State University Nanovaccine Institute
A new class of self-assembling micelles based on pentablock copolymers has been shown to enhance antibody responses and provide a new approach for designing vaccines for older adults. These micelles act as scaffolds for antigen presentation to B cells, cross-linking B cell receptors, and can be used to generate laboratory-scale quantities of therapeutic antibodies against multiple antigens in vitro.
Host antibody responses are pivotal for providing protection against infectious agents. We have pioneered a new class of self-assembling micelles based on pentablock copolymers that enhance antibody responses while providing a low inflammatory environment compared to traditional adjuvants. This type of just-right immune response is critical in the rational design of vaccines for older adults. Here, we report on the mechanism of enhancement of antibody responses by pentablock copolymer micelles, which act as scaffolds for antigen presentation to B cells and cross-link B cell receptors, unlike other micelle-forming synthetic block copolymers. We exploited this unique mechanism and developed these scaffolds as a platform technology to produce antibodies in vitro. We show that this novel approach can be used to generate laboratory-scale quantities of therapeutic antibodies against multiple antigens, including those associated with SARS-CoV-2 and Yersinia pestis, further expanding the value of these nanomaterials to rapidly develop countermeasures against infectious diseases.
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