4.8 Article

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

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Summary: The study evaluates clonal heterogeneity within individual primary tumors and metastases and during different stages of malignant tumor progression, revealing substantial heterogeneity in gene expression. In the mouse model of clonal tracing, chemotherapy mainly targets slow-proliferative clonal populations, which may impact therapy selection and response in breast cancer patients.

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