The study introduces novel phosphine-based reagents that can convert complex azines into fluoroalkylated derivatives. This transformation can impact the biologically relevant properties of compounds.
The installation of -CF3 or -CF2H groups into compounds can impact important biologically relevant properties. In a recent paper published in Nature, McNally, Paton, and co-workers introduce novel phosphine-based reagents that allow for the conversion of a variety of complex azines through C-H functionalization directly into their fluoroalkylated derivatives.
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