期刊
ACS SENSORS
卷 6, 期 6, 页码 2225-2232出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.1c00124
关键词
near-infrared fluorescence; platelets; in vivo imaging; thrombosis; glycoprotein IIb/IIIa
资金
- National Institute of Health [R01HL133153, R01HL122238, R01HL122388, R01HL137913, R01HL150538, R01HL144550]
- National Natural Science Foundation of China [81800431]
The study developed a near-infrared fluorescence probe based on tirofiban, which can rapidly and accurately visualize activated platelets in vivo, offering a potential new application for clinical diagnosis.
Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biological activity of this cell type from a basic experimental focus to a clinical focus, new translatable platelet-specific molecular imaging agents are required. Herein, we report the development of a near-infrared fluorescence probe based upon tirofiban, a clinically approved small-molecule glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa). Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature.
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