期刊
ACS SENSORS
卷 6, 期 6, 页码 2077-2107出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.1c00415
关键词
bio-sensing; quantum sensing; nitrogen-vacancy center; diamond; magnetometry; relaxometry; thermometry; electronic and nuclear spin sensing
资金
- HKSAR Research Grants Council (RGC) [14306117, 27202919]
- HKSAR Innovation and Technology Fund (ITF) through the Platform Projects of the Innovation and Technology Support Programme (ITSP) [ITS/293/19FP]
- HKU
- Guangdong Special Support Project [2019BT02X030]
- MSM Project [8C18004]
- European Regional Development Fund
- OP RDE
- Project CARAT [CZ.02.1.01/0.0/0.0/16_026/0008382]
- Czech Science Foundation [1817071 S]
The nitrogen-vacancy (NV) center is a promising quantum sensor for biomedical applications, with unique optical and spin properties that allow for quantitative measurement of nanoscale electromagnetic fields at room temperature. Its potential in molecular detection and imaging makes it one of the most versatile platforms for various life-science applications.
The long-dreamed-of capability of monitoring the molecular machinery in living systems has not been realized yet, mainly due to the technical limitations of current sensing technologies. However, recently emerging quantum sensors are showing great promise for molecular detection and imaging. One of such sensing qubits is the nitrogen-vacancy (NV) center, a photoluminescent impurity in a diamond lattice with unique room-temperature optical and spin properties. This atomic-sized quantum emitter has the ability to quantitatively measure nanoscale electromagnetic fields via optical means at ambient conditions. Moreover, the unlimited photostability of NV centers, combined with the excellent diamond biocompatibility and the possibility of diamond nanoparticles internalization into the living cells, makes NV-based sensors one of the most promising and versatile platforms for various life-science applications. In this review, we will summarize the latest developments of NV-based quantum sensing with a focus on biomedical applications, including measurements of magnetic biomaterials, intracellular temperature, localized physiological species, action potentials, and electronic and nuclear spins. We will also outline the main unresolved challenges and provide future perspectives of many promising aspects of NV-based bio-sensing.
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