期刊
MOLECULAR THERAPY-ONCOLYTICS
卷 22, 期 -, 页码 307-325出版社
CELL PRESS
DOI: 10.1016/j.omto.2021.07.008
关键词
-
资金
- Research Project of Sichuan Provincial Health Commission [19PJ292]
- Special Support Program for Young Technologists of Southwest Medical University [20064, 20072, 20076]
- Talent Development Project of the Affiliated Hospital of Southwest Medical University
The study identified the prognosis-related MMP25-AS1/hsa-miR-10a-5p/SERPINE1 ceRNA network in KIRC, which could predict patient survival with immune cell infiltration analyzed. A three-gene-based survival predictor model was constructed as a reference for future clinical research. Methylation analyses indicated the abnormal upregulation of SERPINE1 may result from hypomethylation.
Long non-coding RNAs (lncRNAs) play a significant role in multiple human cancers as competing endogenous RNAs (ceR-NAs). However, a systematic mRNA-microRNA (miRNA)-lncRNA network linked to kidney renal clear cell carcinoma (KIRC) prognosis has not been described. In this study, we aimed to identify the prognosis-related ceRNA regulatory network and analyzed its relationship with immune cell infiltration to predict KIRC patient survival. The MMP25-AS1/hsa-miR-10a-5p/SERPINE1 ceRNA network related to the prognosis of KIRC was obtained through bioinformatics analysis based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Meanwhile, we constructed a three-gene-based survival predictor model, which could be referential for future clinical research. Methylation analyses suggested that the abnormal upregulation of the SERPINE1 likely resulted from hypomethylation. Furthermore, the immune infiltration analysis showed that the MMP25-AS1/hsamiR-10a-5p/SER-PINE1 axis could affect the changes in the tumor immune microenvironment and the development of KIRC by affecting the expression of chemokines (CCL4, CCL5, CXCL13, and XCL2). Tumor Immune Dysfunction and Exclusion (TIDE) analysis indicated that the high expression of SERPINE1 might be related to tumor immune evasion in KIRC. In summary, the current study constructing the MMP25-AS1/hsamiR-10a-5p/SERPINE1 ceRNA network might be a novel significant prognostic factor associated with the diagnosis and prognosis of KIRC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据