期刊
COATINGS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/coatings11060680
关键词
titanium oxide nanoparticles; COVID-19; SARS-CoV-2; HRTEM; SEM; TEM; cytotoxicity; 3-(4; 5-dimethylthiazol-2-yl)-2; 5-diphenyl-2H-tetrazolium bromide MTT assay; antiviral activity
资金
- Deanship of the scientific research, Taif University, Ministry of Education, Saudi Arabia [1-441-24]
The study utilized synthesized TiO2-NPs nanotubes for disinfection of SARS-CoV-2, showing strong antiviral activity with low cytotoxicity. Further studies are recommended to explore complex interactions with natural compounds to enhance antiviral efficacy and reduce cytotoxicity.
Synthesized titanium oxide nanoparticles (TiO2-NPs) nanotubes were used for the disinfection of new emerging corona virus-19 (SARS-CoV-2) in this study. The newly synthesized TiO2-NPs (nanotubes) were characterized by chemical spectroscopic analysis Fourier-transform infrared spectroscopy and ultraviolet FT-IR and UV. The chemical purity and Zeta potential distribution of the TiO2-NPs (nanotubes) were evaluated to confirm their nano-range, and their surface morphology was determined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and energy dispersive X-ray analysis (EDX). The antiviral activity of the TiO2-NPs (nanotubes) against SARS-CoV-2 was evaluated using 10% (Dimethyl sulfoxide) DMSO and dist.H2O using a cytotoxicity assay and inhibitory concentration assay (to determine the cytotoxic half concentration CC50 and half maximal inhibitory concentration IC50). The current results confirmed that TiO2-NPs exhibit strong anti-SARS-CoV-2 activity at very low cytotoxic concentrations in vitro with a non-significant selectivity index (CC50/IC50 <= 1). The obtained results indicate that TiO2-NPs and nanotubes have potent antiviral activity at a very low concentrations (IC50 = 568.6 ng/mL), with a weak cytotoxic effect on the cellular host (CC50 = 399.1 ng/mL). Thus, we highly recommend the use of TiO2-NPs (nanotubes) in vitro and in wall coatings as a potent disinfectant to combat SARS-CoV-2 with little irritation of the cellular hosts. Furthermore, we also recommend more and excessive prospective studies on the complexation of natural active or natural compounds with TiO2-NPs (nanotubes) to minimize their cytotoxicity, enhance their antiviral activity, and increase their inhibition of SARS-CoV-2.
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