期刊
COATINGS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/coatings11091024
关键词
polyelectrolyte multilayer; biocompatibility; transport control; biopolymers; polysaccharides; diffusion limiting; biosensors; drug delivery
资金
- National Science Foundation [BES-060037]
Nanoscale bio-polymer coatings play a crucial role in medical device applications, and chemically crosslinking can reduce the diffusivity of glucose, effectively controlling the permeation of small molecules and enhancing biomimetic properties.
Nanoscale coatings are attractive for managing the biological/material interface as well as for transport control in medical device applications. Construction of biologically derived and mimicking polyelectrolyte multilayers (BioPEMs) and their chemically crosslinked derivatives was evaluated at the nanometer scale and the glucose mass transfer properties were characterized in a physiological environment. Glucose diffusivity through all the BioPEMs was found to be three to four orders of magnitude lower than that of bare substrate. In contrast, permeation rates (dC/dt) were significantly higher than when compared to films comprising the same number of bilayers of synthetic materials-poly(acrylic acid)/poly(allylamine hydrochloride). Crosslinked BioPEMs exhibited decreased diffusivity of glucose up to 51% compared to native BioPEMs. These findings provide fundamental insight into the transport properties of BioPEM coatings that may be useful in maximizing biomimetic properties while also controlling permeation of small molecules in applications such as sensors, filtration, and drug delivery systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据