Eco-friendly methoximation of aromatic aldehydes and ketones using MnCl2.4H2O as an easily accessible and efficient catalyst

Methoximes are important as a class of intermediates and products, among fine chemicals and specialties. The development of a new, facile and efficient method for their synthesis is reported. The methoximes were properly accessed from the corresponding aromatic aldehydes and ketones in good to excellent yields, under mild conditions, employing the inexpensive and environmentally friendly MnCl2.4H(2)O as a catalyst (at low loading and without the addition of ligand), in EtOH at 50 degrees C. The scope of the process was systematically assessed.

Automated summary

A new, facile, and efficient method for synthesizing methoximes from aromatic aldehydes and ketones was reported, using environmentally friendly MnCl2.4H(2)O as a catalyst. The method achieved good to excellent yields under mild conditions, without the need for additional ligands.