期刊
FRONTIERS IN ENDOCRINOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.708494
关键词
COVID-19; diabetes; antidiabetic agents; mortality; type 2 diabetes
资金
- National Natural Science Foundation of China [81870593]
- Natural Science Foundation of Shandong Province of China [ZR2020MH106]
- Shandong Province Higher Educational Science and Technology Program for Youth Innovation [2020KJL004]
- Quality Improvement of Postgraduate Education in Shandong Province [SDYAL19156]
The systematic review and meta-analysis found that metformin and sulfonylurea use were associated with lower mortality risk in patients with type 2 diabetes who have COVID-19, while insulin use was linked to higher mortality. There was no significant difference in mortality between DPP-4 inhibitor users and non-users, indicating a need for further exploration of the effects of antidiabetic agents in this population.
Aims:& nbsp;We conducted a systematic review and meta-analysis to assess various antidiabetic agents' association with mortality in patients with type 2 diabetes (T2DM) who have coronavirus disease 2019 (COVID-19). Methods:& nbsp;We performed comprehensive literature retrieval from the date of inception until February 2, 2021, in medical databases (PubMed, Web of Science, Embase, and Cochrane Library), regarding mortality outcomes in patients with T2DM who have COVID-19. Pooled OR and 95% CI data were used to assess relationships between antidiabetic agents and mortality. Results:& nbsp;Eighteen studies with 17,338 patients were included in the meta-analysis. Metformin (pooled OR, 0.69; P=0.001) and sulfonylurea (pooled OR, 0.80; P=0.016) were associated with lower mortality risk in patients with T2DM who had COVID-19. However, patients with T2DM who had COVID-19 and received insulin exhibited greater mortality (pooled OR, 2.20; P=0.002). Mortality did not significantly differ (pooled OR, 0.72; P=0.057) between DPP-4 inhibitor users and non-users. Conclusions:& nbsp;Metformin and sulfonylurea could be associated with reduced mortality risk in patients with T2DM who have COVID-19. Furthermore, insulin use could be associated with greater mortality, while DPP-4 inhibitor use could not be. The effects of antidiabetic agents in patients with T2DM who have COVID-19 require further exploration.
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