期刊
FRONTIERS IN ENDOCRINOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.683040
关键词
Serum magnesium; PCOS; insulin resistance; testosterone; nutrition
资金
- National Public Welfare Projects for Chinese Medicine [201107005, 200807002]
- National Key Discipline of Chinese Medicine in Gynecology [JC200804]
- Intervention for Polycystic Ovary Syndrome Based on Traditional Chinese Medicine Theory-`Tian Gui Disorder' [2011TD006]
- National Clinical Trial Base in Chinese Medicine Special Projects [JDZX2012036, 2015B009]
- Heilongjiang Province 'Longjiang Scholar' Program [H2018051]
The study found that there is a negative association between serum magnesium and insulin resistance index and testosterone level in women with PCOS. Lower levels of serum magnesium are correlated with worsened insulin resistance and higher testosterone levels.
Objective This article aimed to investigate whether serum magnesium is associated with insulin resistance index and testosterone level in women with polycystic ovary syndrome (PCOS). Materials and Methods Overall 1000 women with PCOS were enrolled in a randomized controlled trial and a cross-sectional analysis of the association of serum magnesium with glucose metabolism markers and testosterone was performed. Serum magnesium, glucose metabolism markers and testosterone were measured. Insulin resistance was evaluated by homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin-sensitivity check index (QUICKI). Multivariable linear regression and logistic regression models were used to estimate the association between serum magnesium, insulin resistance and testosterone. Results In comparative analyses, women with higher quartile of serum magnesium had significantly lower fasting glucose, HOMA-IR and testosterone. Multiple linear regression showed serum magnesium was independently negatively associated with insulin, glucose, HOMA-IR, testosterone and positively associated with QUICKI (P for trend <0.05) after adjusting confounding covariates. Logistic regression showed serum magnesium in quartile 1 and 2 were independently associated with insulin resistance status (Quartile 1: OR: 2.15, 95%CI: 1.35-3.40, P = 0.001; Quartile 2: OR: 1.90, 95%CI: 1.20-3.02, P = 0.006), while quartile 1 was marginally associated with hyperandrogenemia status (Quartile 1: OR: 1.45, 95%CI: 0.99-2.11, P = 0.055) after adjusting confounding covariates. Conclusion The current findings suggest that lower serum magnesium was associated with aggravated insulin resistance and higher testosterone levels among women with PCOS.
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