4.7 Review

Prognostic Significance of Altered ATRX/DAXX Gene in Pancreatic Neuroendocrine Tumors: A Meta-Analysis

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Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Wenzel M. Hackeng et al.

Summary: Recent studies have shown that ATRX/DAXX and ALT are important prognostic factors for NF-PanNETs, especially in tumors less than or equal to 2.0 cm. These biomarkers are highly specific for pancreatic origin among NET metastases of unknown primary.
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Immunohistochemically Detected Expression of ATRX, TSC2, and PTEN Predicts Clinical Outcomes in Patients With Grade 1 and 2 Pancreatic Neuroendocrine Tumors

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Summary: The study found that loss of TSC2 or PTEN was associated with significantly shorter overall survival in patients with PNETs, while loss of TSC2 or ATRX was associated with significantly shorter recurrence-free survival. Additionally, loss of ATRX or TSC2 was significantly associated with nodal metastasis. The combined loss of TSC2 and ATRX was identified as an independent prognostic factor for shorter recurrence-free survival in G2 PNETs.

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