期刊
FRONTIERS IN GENETICS
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.717535
关键词
chondroitin sulfate; dermatan sulfate; heparan sulfate; proteoglycan; glycosaminoglycan; connective tissue disorder; skeletal disorder; skin disorder
资金
- Japan Society for the Promotion of Science, Japan [19K07054]
- Research Institute of Meijo University
GAGs and proteoglycans play essential roles in constructing the extracellular matrix, tissue development, and cell signaling. Defects in GAGs and core proteins of proteoglycans may lead to various diseases, including skeletal disorders, heart and kidney defects. Further research is needed on congenital disorders associated with defects in GAG biosynthetic enzymes and core proteins of proteoglycans.
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix. Proteoglycans and GAGs have been demonstrated to exhibit a variety of physiological functions such as construction of the extracellular matrix, tissue development, and cell signaling through interactions with extracellular matrix components, morphogens, cytokines, and growth factors. Not only connective tissue disorders including skeletal dysplasia, chondrodysplasia, multiple exostoses, and Ehlers-Danlos syndrome, but also heart and kidney defects, immune deficiencies, and neurological abnormalities have been shown to be caused by defects in GAGs as well as core proteins of proteoglycans. These findings indicate that GAGs and proteoglycans are essential for human development in major organs. The glycobiological aspects of congenital disorders caused by defects in GAG-biosynthetic enzymes including specific glysocyltransferases, epimerases, and sulfotransferases, in addition to core proteins of proteoglycans will be comprehensively discussed based on the literature to date.
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