4.6 Article

Association Between Human Leukocyte Antigen Class I and II Diversity and Non-virus-associated Solid Tumors

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FRONTIERS IN GENETICS
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.675860

关键词

association; Caucasian; human leukocyte antigen; solid tumor; zygosity

资金

  1. National Cancer Institute Intramural Research Program, United States
  2. NIH
  3. NCI
  4. United States Public Health Service from the NCI, Department of Health and Human Services [N01-CN-45165, N01-RC-45035, N01-RC-37004, HHSN261201000006C]
  5. NIH Genes, Environment and Health Initiative (GEI) [HG-06-033-NCI-01, RO1HL091172-01, U01HG004438, NIH HHSN268200782096C, U01 HG004446]
  6. NCI, NIH, Department of Health and Human Services
  7. NCI, NIH [N01-CO-12400]
  8. NIH, NCI, Division of Cancer Epidemiology and Genetics [N02-CP-01037]
  9. NCI [NO1-CN-25514, NO1-CN-25522, NO1-CN-25515, NO1-CN-25513, NO1-CN-25512, NO1CN-25516, NO1-CN-25511, NO1-CN-25524, NO1-CN-25518, NO1-CN-75022, NO1-CN-25476, NO1-CN-25404]
  10. NIH, NCI, Division of Cancer Epidemiology and Genetics
  11. NCI, United States

向作者/读者索取更多资源

The study found no evidence to suggest a strong relationship between HLA zygosity and the risk of non-virus-associated solid tumors based on genome-wide association study data from over 28,000 individuals of European ancestry.
Homozygosity at human leukocyte antigen (HLA) loci might lead to reduced immunosurveillance and increased disease risk, including cancers caused by infection or of hematopoietic origin. To investigate the association between HLA zygosity and risk of non-virus-associated solid tumors, we leveraged genome-wide association study (GWAS) data from over 28,000 individuals of European ancestry who participated in studies of 12 cancer sites (bladder, brain, breast, colon, endometrial, kidney, lung, ovary, pancreas, prostate, skin, and testis). Information on HLA zygosity was obtained by imputation; individuals were classified as homozygotes at a given locus when imputed to carry the same four-digit allele at that locus. We observed no evidence for an association between zygosity at six HLA loci and all cancers combined. Increase in number of homozygous at HLA class I loci, class II loci, or class I and II loci was also not associated with cancer overall (P-trend = 0.28), with adjusted odds ratios (ORs) for risk-per-locus of 1.00 [95% confidence intervals (CIs) = 0.97, 1.03], 1.02 (0.99, 1.04), and 1.01 (0.99, 1.02), respectively. This study does not support a strong role for HLA zygosity on risk of non-virus-associated solid tumors.

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