期刊
FRONTIERS IN GENETICS
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.693259
关键词
ovarian cancer; drug resistance; microRNA; long non-coding RNA; circular RNA
资金
- Independent Exploration and Innovation Project for Graduate Students of Central South University [2021zzts1080]
- Philosophy and Social Science Foundation Project of Hunan Province [19YBA349]
- Clinical Medical Technology Innovation Guidance Plan of Hunan Province [2020SK53607]
- Natural Science Foundation of Changsha [kq2014261]
Ovarian cancer, a common gynecological malignancy with high mortality rate, can benefit from chemotherapy but drug resistance remains a challenge. ncRNAs, such as circular RNAs, long non-coding RNAs, and microRNAs, play important roles in ovarian cancer development and resistance to chemotherapy. Understanding the regulatory mechanisms by which ncRNAs affect chemoresistance may lead to new diagnostic and therapeutic strategies for ovarian cancer.
Ovarian cancer is one of the most common gynecological malignancies with highest mortality rate among all gynecological malignant tumors. Advanced ovarian cancer patients can obtain a survival benefit from chemotherapy, including platinum drugs and paclitaxel. In more recent years, the administration of poly-ADP ribose polymerase inhibitor to patients with BRCA mutations has significantly improved the progression-free survival of ovarian cancer patients. Nevertheless, primary drug resistance or the acquisition of drug resistance eventually leads to treatment failure and poor outcomes for ovarian cancer patients. The mechanism underlying drug resistance in ovarian cancer is complex and has not been fully elucidated. Interestingly, different non-coding RNAs (ncRNAs), such as circular RNAs, long non-coding RNAs and microRNAs, play a critical role in the development of ovarian cancer. Accumulating evidence has indicated that ncRNAs have important regulatory roles in ovarian cancer resistance to chemotherapy reagents and targeted therapy drugs. In this review, we systematically highlight the emerging roles and the regulatory mechanisms by which ncRNAs affect ovarian cancer chemoresistance. Additionally, we suggest that ncRNAs can be considered as potential diagnostic and prognostic biomarkers as well as novel therapeutic targets for ovarian cancer.
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