期刊
CANCER MANAGEMENT AND RESEARCH
卷 13, 期 -, 页码 5317-5336出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S314502
关键词
lncRNA; cancer progression; glycolysis; signaling pathway
类别
资金
- Foundation of Science and Technology Department of Sichuan Province [2020YJ0147]
- Foundation of apricot grove scholar ofChengdu University of Traditional Chinese Medicine [2019yky09]
- Postdoctoral Science Foundation of Chengdu University of Traditional Chinese Medicine [030054080]
This review discusses the regulatory mechanisms of LncRNAs in aerobic glycolysis in cancer cells, highlighting their impact on cancer progression. A comprehensive understanding of these regulatory mechanisms can provide new strategies for clinical cancer management.
Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management.
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