期刊
FRONTIERS IN CHEMISTRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2021.710808
关键词
supramolecular chemistry; photodynamic agent; calixarene; fullerene; solubility
资金
- NSFC [U20A20259, 31961143004]
- Fundamental Research Funds for the Central Universities
- NCC Fund [NCC2020FH04]
A water-soluble supramolecular nanoformulation based on SAC4A and fullerene was developed to overcome the hydrophobicity of fullerene and used as a potential photodynamic agent. The significantly increased water solubility of fullerene enables efficient activation of reactive oxygen species, expanding the biomedical applications of fullerene through a host-guest strategy.
Fullerene has attracted much attention in biomedical research due to its unique physical and chemical properties. However, the hydrophobic nature of fullerene is limited to deploy in the body, given that the biofluids are mainly water. In this study, a water-soluble supramolecular nanoformulation based on a deep cavitand calixarene (SAC4A) and fullerene is developed to overcome the hydrophobicity of fullerene and is used as a potential photodynamic agent. SAC4A solubilizes fullerene very well with a simple grinding method. The significantly increased water solubility of fullerene enables efficient activation of reactive oxygen species. The host-guest strategy to solubilize fullerene can not only provide a new method to achieve water solubility but also expand the biomedical applications of fullerene.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据