4.6 Review

Photodynamic Therapy for the Treatment and Diagnosis of Cancer-A Review of the Current Clinical Status

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Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy

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Summary: Photodynamic technology utilizes light-sensitive and fluorescent substances to accurately diagnose various malignancies by accumulating specifically in tumor cells. This technology enables precise diagnosis and complete resection during surgery, making it a potential treatment option for cancer.

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Summary: Cancer is a major global health issue and photodynamic therapy using photosensitizers is an approved therapeutic option. The success of this therapy depends on the quality and improvement of photosensitizer drugs, with bioconjugation and encapsulation with targeting moieties playing a key role in developing more efficient photosensitizers for cancer treatment. Despite significant advances, the development of next-generation photosensitizers is still mainly in the developmental stage.

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Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment

Huanyu Yang et al.

Summary: Current clinical studies review the use of photodynamic therapy with nanoparticles in treating pancreatic cancer. Nanoparticles have advantages in improving the efficacy of photodynamic therapy for pancreatic cancer treatment. Challenges and future outlook in developing nanoparticle-based photodynamic therapy for pancreatic cancer are discussed.

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Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Razan Alzeibak et al.

Summary: The past decade has seen significant breakthroughs in cancer immunotherapy, with immunogenic cell death (ICD) emerging as a promising approach to eliminate tumor cells. Photodynamic therapy (PDT) can induce ICD, but its efficiency is reduced in hypoxic tumor environments. Future research may focus on strategies like oxygen-boosted PDT and nanotechnology to address this limitation.

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Recent Advances in Photodynamic Therapy for Deep-Seated Tumors with the Aid of Nanomedicine

Wei-Peng Li et al.

Summary: Photodynamic therapy (PDT) is a treatment method that activates a photosensitizer in a tumor using light, and is currently limited to superficial and thin tumors. Advances in nanomedicine hold promise for expanding its application to deep-seated tumors.

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

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Photodynamic therapy to control microbial biofilms

Anjali Warrier et al.

Summary: Microorganisms in biofilms show increased resistance to antibiotics, prompting the need for advanced antimicrobial approaches. Photodynamic therapy, as a safe and non-toxic treatment strategy, is increasingly used for chronic infections, extending its potential applications in various medical conditions.

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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Jang-June Park et al.

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Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers

Johannes Karges et al.

Summary: This study presents a method to encapsulate a promising Ru(II) polypyridine complex in polymer nanoparticles, improving the selectivity and efficacy of photodynamic therapy. The nanoparticles exhibit high phototoxicity towards cancer cells and are effective in drug resistant cancer cells, indicating their potential to overcome drug resistance.

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Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

Zijun Shen et al.

Summary: Photodynamic therapy is a promising tumor treatment technology, but tumor hypoxia hinders its effectiveness. Various strategies, including oxygen carriers and multimodal therapy, have been explored to overcome the limitations caused by hypoxia and improve therapeutic outcomes.

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Adelina-Gabriela Niculescu et al.

Summary: The healing power of light has attracted interest for thousands of years, resulting in the emergence of photodynamic therapy as a promising approach in treating various diseases. However, classic photosensitizing compounds have limitations in clinical applications, which nanotechnology aims to overcome by improving targeting efficiency, release control, and solubility.

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Photodynamic Antimicrobial Chemotherapy: Advancements in Porphyrin-Based Photosensitize Development

James Oyim et al.

Summary: The reduction of available drugs effective against microbes is worsening due to global antimicrobial resistance crisis. Innovative strategies, like Photodynamic Antimicrobial Chemotherapy (PACT), are needed to combat this. PACT utilizes light, oxygen, and a photosensitizer to destroy a wide spectrum of microorganisms, including resistant strains, showing promise in addressing antimicrobial resistance.

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Factors Determining the Susceptibility of Bacteria to Antibacterial Photodynamic Inactivation

Aleksandra Rapacka-Zdonczyk et al.

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From molecules to nanovectors: Current state of the art and applications of photosensitizers in photodynamic therapy

A. Verger et al.

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The sustaining of fluorescence in photodynamic diagnosis after the administration of 5-aminolevulinic acid in carcinogen-induced bladder cancer orthotopic rat model and urothelial cancer cell lines

Takuya Owari et al.

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Kai Wang et al.

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Vinayak Bhandari et al.

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Reema Railkar et al.

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Francesco Borgia et al.

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Jinjin Shi et al.

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Keiji Inoue

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Taher Gheewala et al.

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Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8+ T Cells

Jan Willem Kleinovink et al.

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Photosensitizer in lipid nanoparticle: a nano-scaled approach to antibacterial function

Bishakh Rout et al.

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Nanoparticles for Advanced Photodynamic Therapy of Cancer

Heidi Abrahamse et al.

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Ushasri Chilakamarthi et al.

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Ling Yang et al.

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A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

Ilke Simsek Turan et al.

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Ursodeoxycholic acid-conjugated chitosan for photodynamic treatment of HuCC-T1 human cholangiocarcinoma cells

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Antioxidant Inhibitors Potentiate the Cytotoxicity of Photodynamic Therapy

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Mathias O. Senge

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