期刊
ACS CENTRAL SCIENCE
卷 7, 期 9, 页码 1454-1462出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.1c00594
关键词
-
资金
- NIH [GM62160, GM125271, 1721852308]
The complexity and irreproducibility of glycosylation reactions hinder the progress of glycosciences. Applying the steady-state hypothesis to transient oxocarbenium ion-counterion pair intermediates reveals the significance of factors like concentration, temperature in glycosylation stereoselectivity. Guidelines have been proposed for the practice of O-glycosylation reactions, allowing for the establishment of more reproducible and practical protocols.
The complexity and irreproducibility of glycosylation reactions retard progress the glycosciencs. Application of the steady-state hypothesis to transient oxocarbenium ion-counterion pair intermediates reveals the importance of concentration, temperature, and other factors in glycosylation stereoselectivity. Guidelines are then adduced for the practice of O-glycosylation reactions on the oasis of which more reproducible, practical protocols can be established.
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