☆ 4.7 Editorial Material

Total Synthesis of Poisonous Aconitum Alkaloids Empowered by a Fragment Coupling Strategy

ACS CENTRAL SCIENCE (2021)

Fragment Coupling Reactions in Total Synthesis That Form Carbon-Carbon Bonds via Carbanionic or Free Radical Intermediates

Martin Tomanik et al.

Summary: Fragment coupling reactions that form carbon-carbon bonds are important transformations in synthetic design. In recent years, there has been an increase in fragment couplings proceeding via carbanionic and open-shell intermediates. These reactions provide predictability and reliability, while also offering valuable lessons for students.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Total Syntheses of the C19 Diterpenoid Alkaloids (-)-Talatisamine, (-)-Liljestrandisine, and (-)-Liljestrandinine by a Fragment Coupling Approach

Alice R. Wong et al.

Summary: C19 diterpenoid alkaloids are a large family of natural products that modulate the activity of ion channels in vivo, making them of interest for studying neurological and cardiovascular diseases. The complex structures of these molecules continue to challenge chemical synthesis, and researchers have successfully completed the total syntheses of three aconitine-type C19 DTAs using a fragment coupling strategy.

ACS CENTRAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary