4.7 Article

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

期刊

REDOX BIOLOGY
卷 42, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.redox.2021.101959

关键词

Peroxiredoxin; Redox signaling; Post-translational modification (PTM); Protein-protein interactions (PPI); Prx; Prdx

资金

  1. VIB grant
  2. Research Foundation-Flanders-Fonds de la Recherche Scientifique Excellence of Science project [30829584]
  3. Chinese Scholarship Council [201707650018]

向作者/读者索取更多资源

This review provides a tabulated overview of human and bacterial peroxiredoxins, focusing on structure, post-translational modifications, and protein-protein interactions. The study aims to understand the cellular operating power of Prdxs in both stress and non-stress conditions, utilizing various experimental techniques at cellular and atomic levels. Future research is needed to gain a clearer view on the specificities and functions of peroxiredoxins in different cellular contexts.
Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.

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