4.5 Review

Atopy: A Collection of Comorbid Conditions

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Summary: This study utilized RNA-seq analysis of tape strips from lesional and nonlesional skin of patients with moderate-to-severe AD and psoriasis, revealing distinct immune and barrier signatures in the two diseases. The findings suggest the potential utility of tape strips as a minimally invasive alternative to biopsies for detecting disease biomarkers. Differences in gene expression profiles between AD and psoriasis highlight the unique pathophysiological mechanisms of these two skin disorders.

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Summary: The developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses are associated with the risk of childhood asthma. A Staphylococcus-dominant microbiome in early infancy is linked to an increased risk of recurrent wheezing and persistent asthma, while detection of rhinoviruses and predominance of Moraxella during wheezing illnesses are associated with asthma that persists throughout later childhood.

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