Atopy: A Collection of Comorbid Conditions

The concept of atopy was initially developed in the first quarter of the 20th century on the basis of clinical observations without any knowledge of pathogenic mechanisms. Atopy involves a collection of comorbidities that share pathogenic features, and atopic comorbidities affect outcomes of concomitant conditions rather than existing synchronously. The clinical importance of understanding the relationship of these conditions is necessary because the treatment of one condition influences the others, and the development of one leads to or precedes the development of another. Environmental influences and multigenetic predispositions result in complex relationships among the atopic conditions sharing a type 2 pathogenesis. The specialty of Allergy and Immunology is devoted to managing the comorbidities of atopy, and better understanding of their connections can improve patient care. (C) 2021 American Academy of Allergy, Asthma & Immunology

Automated summary

The concept of atopy was developed in the early 20th century based on clinical observations without knowledge of pathogenic mechanisms. It involves a collection of comorbidities that share pathogenic features, and understanding the relationships between these conditions is crucial for improving patient care. Specialized in Allergy and Immunology focus on managing the comorbidities of atopy, and better understanding their connections can enhance patient care.