Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD

Asthma is a complex disease with heterogeneous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease cooccur in patients with asthma at higher rates than in those without asthma. Although these diseases share risk factors, there are some data suggesting that these comorbidities have shared inflammatory pathways, drive the development of asthma, or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations, and key knowledge gaps of these common comorbidities. Crown Copyright (C) 2021 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology

Automated summary

Asthma is a complex disease with heterogeneous phenotypes and endotypes. Common comorbidities such as obesity, obstructive sleep apnea, and gastroesophageal reflux disease may share inflammatory pathways and worsen asthma control.