期刊
FRONTIERS IN NEUROLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2021.697923
关键词
visual snow; palinopsia; migraine; positive persistent visual disturbance; thalamocortical dysrhythmia; colour filter
资金
- North American Neuro-Ophthalmology Society Pilot grant
The study found that visual snow symptoms are influenced by color modulation, particularly in increasing levels of S-cone excitation. Patients prefer orange-yellow and turquoise-blue spectral regions that relieve symptoms, while a non-preferred violet region near the tritanopic confusion line exacerbates symptoms.
Background and Purpose: Visual Snow (VS) is a disorder characterised by the subjective perception of black-and-white visual static. The aetiology of this condition is not known. In our previous work we suggested that there is a link between short-wave (S or blue cone) signals and severity of visual snow symptoms. Therefore we aimed to further characterise this potential link. Methods: Patients (n = 22) with classic VS based on the diagnostic criteria and healthy controls (n = 12), underwent Intuitive Colorimetry (IC) testing (Cerium Visual Technologies). Twelve hue directions (expressed as angle in CIE 1976 LUV space relative to D65) were rated on a five-point scale from preferred (relieving, positive score) to non-preferred (exacerbating, negative score), and overall preferred and non-preferred angles were chosen. Results: A non-preferred violet region near the tritanopic confusion line /S-cone axis (267 deg.) was strongly associated with exacerbation of VS symptoms (range 250-310 deg, mean 276 +/- 16, n = 20, Rayleigh p < 0.001). Two subjects with non-preferred region > 90 deg from mean were considered as outliers. Median rank at hue angle 270 deg was significantly lower than at angle 90 (-1.5 vs. 0.0, p < 0.001, Wilcoxon non-parametric rank-sum test). Patients showed preference for one of two spectral regions which relieved VS symptoms: orange-yellow (range 50-110 deg., mean 79 +/- 24, n = 14) and turquoise-blue (range (210-250 deg., mean 234 +/- 27, n = 8). Conclusion: Our results show that visual snow symptoms are exacerbated by colour modulation that selectively increased levels of S-cone excitation. Because S-cone signals travel on primordial brain pathways that regulate cortical rhythms (koniocellular pathways) we hypothesis that these pathways contribute to the pathogenesis of this disorder.
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