期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.666163
关键词
COVID-19; SARS-CoV-2; influenza; whole blood transcriptome; RNA-sequencing; immune profiling
类别
资金
- Swiss National Science Foundation [31CA30_196036, 33IC30_179636, 314730_ 192616, 31003A_176097]
- Leenaards Foundation
- Santos-Suarez Foundation
- Carigest
- Swiss National Science Foundation (SNF) [31CA30_196036, 31003A_176097, 314730_192616, 33IC30_179636] Funding Source: Swiss National Science Foundation (SNF)
The dysregulated immunity in COVID-19 patients plays a key role in the severity of the disease, including defects in IFN responses, reduced toxicity-related molecules in NK cells, and increased neutrophil degranulation. Additionally, differences in gene expression patterns are also determinants of COVID-19 severity.
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
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