期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.692051
关键词
meningeal lymphatic vessels; neuromyelitis optica spectrum disorders; acute relapse; DCE-MRI; superior sagittal sinus
类别
资金
- National Natural Science Foundation of China [81873791, 81471307]
- Natural Science Foundation of Henan Province for Excellent Young Scholars [202300410357]
The study identified slowed flow through meningeal lymphatic vessels (mLVs) in patients with acute neuromyelitis optica spectrum disorders (NMOSD) compared to those in chronic phase, with the flow speed correlating with disease severity evaluated by expanded disability status scale (EDSS). Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may offer objective evidence to predict NMOSD acute relapse by evaluating mLVs function. Promoting or restoring the function of mLVs may present a new target for NMOSD relapse treatment.
The meningeal lymphatic vessels (mLVs) in central nervous system (CNS) have been validated by rodent and human studies. The mLVs play a vital role in draining soluble molecules and trafficking lymphocytes, antigens and antibodies from CNS into cervical lymph nodes (CLNs). This indicates that mLVs may serve as a link between the CNS and peripheral immune system, perhaps involving in the neuroinflammatory disease. However, the morphology and drainage function of mLVs in patients with neuroinflammatory disease, such as neuromyelitis optica spectrum disorders (NMOSD), remains unexplored. Using the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), we found that slower flow through mLVs along superior sagittal sinus in NMOSD patients with acute attack instead of NMOSD patients in chronic phase. The reduced flow in mLVs correlated with the disease severity evaluated by expanded disability status scale (EDSS). The receiver operating characteristic curve (ROC) indicated DCE-MRI might provide objective evidence to predict the acute relapse of NMOSD through evaluating the function of mLVs. Promoting or restoring the function of mLVs might be a new target for the treatment of NMOSD relapse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据