期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.687551
关键词
T cell; postmenopausal osteoporosis; estrogen loss; osteoimmunology; chronic inflammation
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Disease of the NIH [RO1AR064821, RO1AR068438]
- Washington University Musculoskeletal Research Core [NIH P30 AR057235]
Osteoporosis, a common metabolic bone disease, particularly affects middle-aged and elderly women. Menopause is a leading cause of primary osteoporosis in women, and there is a growing recognition of the role of the adaptive immune system in the development of postmenopausal osteoporosis.
Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone resorption that leads to low bone mass, compromised microarchitecture and structural deterioration that increases the likelihood of fracture with minimal trauma, known as fragility fractures. Several factors contribute to osteoporosis in men and women. In women, menopause - the cessation of ovarian function, is one of the leading causes of primary osteoporosis. Over the past three decades there has been growing appreciation that the adaptive immune system plays a fundamental role in the development of postmenopausal osteoporosis, both in humans and in mouse models. In this review, we highlight recent data on the interactions between T cells and the skeletal system in the context of postmenopausal osteoporosis. Finally, we review recent studies on the interventions to ameliorate osteoporosis.
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