期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.693054
关键词
SARS-CoV-2; immune aging; naive T cells; cellular immunity; epitopes; primary responses; CD8(+) T cells
类别
资金
- CRASH CAGE - One-Health Target project - Ludwig Maximillians University, Center for International Health from the Exceed Program of German Academic Exchange Services (DAAD)
Research indicates that older individuals have defective primary SARS-CoV-2-specific CD8(+) T-cell responses, with lower magnitude and quality compared to younger adults, as well as recognizing a lower number of epitopes.
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8(+) T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8(+) T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8(+) T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8(+) T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8(+) T-cell responses.
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