期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.727580
关键词
Mycobacterium leprae; B lymphocytes; B cell differentiation; active immune response; erythema nodosum leprosum
类别
资金
- The New York Community Trust/Heiser Program for Research on Leprosy
- The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIAID/NIH) [RO1AI129835]
This study analyzed the profile of B cell subpopulations in leprosy patients and found that Mycobacterium leprae infection could alter the proportions of B cell subpopulations. The modulation in B cell subpopulations was associated with an increase in total IgG levels and the patient's clinical condition, indicating that circulating B cells may be involved in modulating the immune response to M. leprae in patients with leprosy.
Despite being treatable, leprosy still represents a major public health problem, and many mechanisms that drive leprosy immunopathogenesis still need to be elucidated. B cells play important roles in immune defense, being classified in different subgroups that present distinct roles in the immune response. Here, the profile of B cell subpopulations in peripheral blood of patients with paucibacillary (TT/BT), multibacillary (LL/BL) and erythema nodosum leprosum was analyzed. B cell subpopulations (memory, transition, plasmablasts, and mature B cells) and levels of IgG were analyzed by flow cytometry and ELISA, respectively. It was observed that Mycobacterium leprae infection can alter the proportions of B cell subpopulations (increase of mature and decrease of memory B cells) in patients affected by leprosy. This modulation is associated with an increase in total IgG and the patient's clinical condition. Circulating B cells may be acting in the modulation of the immune response in patients with various forms of leprosy, which may reflect the patient's ability to respond to M. leprae.
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