4.8 Article

Altered Metabolic Phenotype of Immune Cells in a Spontaneous Autoimmune Uveitis Model

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

NAD+ metabolism and its roles in cellular processes during ageing

Anthony J. Covarrubias et al.

Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Immunology

Chronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs

Isabella-Maria Giese et al.

Summary: The study found reduced proliferative response in T cells and distinct changes in protein abundances in CD4(+) T cells of diabetic pigs. Additionally, altered metabolic immune cell phenotype with increased mitochondrial oxygen consumption rate and higher basal glycolytic activity was observed in PBMC of diabetic pigs. The research provides new insights into molecular mechanisms of dysregulated immune cells triggered by permanent hyperglycemia.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4+ T Cell Differentiation and Metabolism

Minkyung Kang et al.

Summary: The lack of IRF4 in T cells confers resistance to experimental autoimmune uveitis (EAU) by inhibiting pathogenic responses of Th17 cells and inducing expansion of regulatory lymphocytes that secrete IL-10 and/or IL-35. CD4-IRF4KO T cells show alterations in cell metabolism and defects in the expression of Ikaros zinc-finger transcription factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Redox regulation of immunometabolism

Jonathan Muri et al.

Summary: Immunometabolism research has revealed the significant impact of metabolic pathways and redox systems on immune cell functions, including the role of reactive oxygen species (ROS) and antioxidant pathways like thioredoxin and glutathione pathways. Studies show the central role of metabolism in determining the fate and function of immune cells, with cellular activation inducing profound changes in their oxidation-reduction system.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Cell Biology

Targeting immunometabolism as an anti-inflammatory strategy

Eva M. Palsson-McDermott et al.

CELL RESEARCH (2020)

Article Biochemistry & Molecular Biology

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

Daniel Missailidis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Ophthalmology

Medical Therapy of Uveitic Macular Edema: Biologic Agents

Aleksandra Radosavljevic et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2020)

Article Cell Biology

Aberrant Migratory Behavior of Immune Cells in Recurrent Autoimmune Uveitis in Horses

Carmen Wiedemann et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Immunology

Regulations of Glycolytic Activities on Macrophages Functions in Tumor and Infectious Inflammation

Qing Yu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Immunology

Immune cell metabolism in autoimmunity

X. Teng et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2019)

Review Endocrinology & Metabolism

Micromanaging aerobic respiration and glycolysis in cancer cells

Ayla V. Orang et al.

MOLECULAR METABOLISM (2019)

Review Immunology

Immunometabolism: an overview and therapeutic prospects in autoimmune diseases

Chrysoula Stathopoulou et al.

IMMUNOTHERAPY (2019)

Article Rheumatology

Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus

Yusuke Takeshima et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

Review Cell Biology

The Science and Translation of Lactate Shuttle Theory

George A. Brooks

CELL METABOLISM (2018)

Review Immunology

Unraveling the Complex Interplay Between T Cell Metabolism and Function

Ramon I. Klein Geltink et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

Article Biochemical Research Methods

Formin like 1 expression is increased on CD4+T lymphocytes in spontaneous autoimmune uveitis

Roxane L. Degroote et al.

JOURNAL OF PROTEOMICS (2017)

Review Immunology

Mitochondrial control of immunity: beyond ATP

Manan M. Mehta et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Veterinary Sciences

Prognosis and impact of equine recurrent uveitis

J. C. Gerding et al.

EQUINE VETERINARY JOURNAL (2016)

Article Biochemistry & Molecular Biology

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Michael D. Buck et al.

Review Medicine, Research & Experimental

Autoimmune uveitis: clinical, pathogenetic, and therapeutic features

Marcella Prete et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2016)

Review Immunology

A guide to immunometabolism for immunologists

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Cell Biology

Normalization of CD4+ T cell metabolism reverses lupus

Yiming Yin et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Immunology

Targeting T cell metabolism for therapy

David O'Sullivan et al.

TRENDS IN IMMUNOLOGY (2015)

Review Veterinary Sciences

Equine recurrent uveitis: Human and equine perspectives

Fernando Malalana et al.

VETERINARY JOURNAL (2015)

Article Biochemistry & Molecular Biology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chih-Hao Chang et al.

Article Multidisciplinary Sciences

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

Article Ophthalmology

Identification of immunodominant epitopes of alpha-crystallins recognized by antibodies in sera of patients with uveitis

Deshka Doycheva et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2012)

Article Immunology

Complement factor B expression profile in a spontaneous uveitis model

Johanna K. Zipplies et al.

IMMUNOBIOLOGY (2010)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Article Ophthalmology

Equine recurrent uveitis - A spontaneous horse model of uveitis

Cornelia A. Deeg et al.

OPHTHALMIC RESEARCH (2008)

Review Physiology

Hypoxia-induced reactive oxygen species formation in skeletal muscle

Thomas L. Clanton

JOURNAL OF APPLIED PHYSIOLOGY (2007)

Article Veterinary Sciences

Recurrent uveitis in horses: Vitreal examinations with ultrastructural detection of leptospires

K. Brandes et al.

JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE (2007)

Article Ophthalmology

High incidence of antibodies to lens proteins in sera from patients with uveitis

Doycheva Deshka et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2007)

Article Biochemical Research Methods

Identification and functional validation of novel autoantigens in equine uveitis

Cornelia A. Deeg et al.

MOLECULAR & CELLULAR PROTEOMICS (2006)

Article Veterinary Sciences

Serum and vitreous humor antibody titers in and isolation of Leptospira interrogans from horses with recurrent uveitis

B Wollanke et al.

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION (2001)