期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.737083
关键词
humoral immunity; antibody subclasses; COVID-19; variants of concern; mRNA vaccination
类别
资金
- Generalitat de Catalunya, Department of Health
- Miguel Servet research program
- National Health Institute Carlos III (ISCIII) (European Regional Development Fund/European Social Fund a way to make Europe) [COV20_00508]
mRNA-1273 vaccine induces cross-variant antibody responses in individuals with or without pre-existing immunity against SARS-CoV-2, with higher titers of IgG1 and IgA in those with prior infection history. COVID-19 recovered subjects do not show a recall antibody response upon the second vaccine dose, but still maintain higher levels of certain antibodies compared to fully vaccinated naive individuals.
mRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of vaccine-induced antibody responses to the original strain and emerging variants of concern remain largely unknown. Here we characterized serum antibody classes and subclasses targeting the spike receptor-binding domain of SARS-CoV-2 wild type and alpha, beta, gamma and delta variants in a longitudinal cohort of SARS-CoV-2 naive and COVID-19 recovered individuals receiving the mRNA-1273 vaccine. We found that mRNA-1273 vaccine recipients developed a SARS-CoV-2-specific antibody response with a subclass profile comparable to that induced by natural infection. Importantly, these antibody responses targeted both wild type SARS-CoV-2 as well as its alpha, beta, gamma and delta variants. Following primary vaccination, individuals with pre-existing immunity showed higher induction of all antibodies but IgG3 compared to SARS-CoV-2-naive subjects. Unlike naive individuals, COVID-19 recovered subjects did not mount a recall antibody response upon the second vaccine dose. In these individuals, secondary immunization resulted in a slight reduction of IgG1 against the receptor-binding domain of beta and gamma variants. Despite the lack of recall humoral response, vaccinees with pre-existing immunity still showed higher titers of IgG1 and IgA to all variants analyzed compared to fully vaccinated naive individuals. Our findings indicate that mRNA-1273 vaccine triggered cross-variant antibody responses with distinct profiles in vaccinees with or without pre-existing immunity and suggest that individuals with prior history of SARS-CoV-2 infection may not benefit from the second mRNA vaccine dose with the current standard regimen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据