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Circular RNA as an Additional Player in the Conflicts Between the Host and the Virus

期刊

FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.602006

关键词

circRNA; viral infection; innate immunity; host defense; host-virus interactions

资金

  1. DBT/Wellcome Trust India Alliance [IA/I/18/2/504006]
  2. MHRD
  3. CSIR
  4. UGC

向作者/读者索取更多资源

Circular RNA (circRNA) is a relatively new member of the non-coding RNA family that plays important roles in regulating gene expression, potential coding, and interactions with proteins and microRNAs. The changes in circRNAs during viral infections can modulate the response to infection, and viruses have been found to encode circRNAs with proviral functions.
Circular RNA (circRNA), a relatively new member of the non-coding RNA family, has spurred great interest among researchers following its discovery as a ubiquitous class within the RNA world. Rapid progress in circRNA biology has coincided with its identification in a plethora of diverse roles including regulation of gene expression and probable coding potential, as well as competing interactions with proteins and microRNAs in various pathological conditions. Emerging evidence suggests that circRNAs also function in viral infections. The deregulation of circRNAs during viral infection has prompted investigations into the possibilities of circRNA as a competing endogenous RNA (ceRNA) that modulates response to infection. Recently, viruses have been shown to encode circRNAs with proviral functions, providing a strong impetus for focused efforts to elucidate the networks coaxed by circRNAs during infection. This review elaborates on recent insights gained on the roles of circRNAs during virus infection and immunity.

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